Angiotensin II Receptor Antagonists, Uses, Side Effects, Dosage Guideline

Angiotensin II Receptor Antagonists,

USES

Treatment of hypertension (HTN) alone or in combination with other antihypertensives. Treatment of heart failure (HF).

ACTION

Angiotensin II receptor antagonists (AIIRA) block vasoconstrictor and aldosterone-secreting effects on angiotensin II by selectively blocking the binding of angiotensin II to AT1 receptors in vascular smooth muscle and the adrenal gland, causing vasodilation and a decrease in aldosterone effects.

 

Angiotensin II Receptor Antagonists, Uses, Side Effects and Dosage Guideline.

 

Name	Availability	Uses	Dosage Range (per day)	Side Effects
Azilsartan (Edarbi) Candesartan (Atacand)	T: 40 mg, 80 mg T: 4 mg, 8 mg, 16 mg, 32 mg	HTN HTN HF	40–80 mg once daily 8–32 mg in 1–2 divided doses 4–32 mg once daily	Diarrhea, hypotension, muscle spasms, weakness Headaches, upper respiratory tract infection, pain, dizziness
Eprosartan (Teveten)	T: 400 mg, 600 mg	HTN	400–800 mg in 1–2 divided doses	Headaches, upper respiratory tract infection, myalgia
Irbesartan (Avapro)	T: 75 mg, 150 mg, 300 mg	HTN Nephropathy	150–300 mg once daily 150–300 mg once daily 300 mg once daily	Headaches, upper respiratory tract infection
Losartan (Cozaar)	T: 25 mg, 50 mg, 100 mg	HTN Nephropathy	25–100 mg in 1–2 divided doses 100 mg once daily	Dizziness, headaches, upper respiratory tract infection, diarrhea, fatigue, cough
Olmesartan (Benicar)	T: 5 mg, 20 mg, 40 mg	HTN	20–40 mg once daily	Headaches, upper respiratory tract infection, flu-like symptoms, dizziness, bronchitis, rhinitis, back pain, pharyngitis, sinusitis, diarrhea, peripheral edema
Telmisartan (Micardis) Valsartan (Diovan)	T: 40 mg, 80 mg T: 80 mg, 160 mg	HTN CV risk reduction HTN HF Post MI	20–80 mg once daily 80 mg once daily 80–320 mg once daily 40–160 mg 2 times/day 20–160 mg 2 times/day	Upper respiratory tract infection, dizziness, back pain, sinusitis, diarrhea Dizziness, headaches, upper respiratory tract infection, diarrhea, fatigue