Anti-convulsants Drugs are used in Seizure disorders; acute, isolated seizures not caused by seizure disorders; status epilepticus; prevention of seizures after trauma or craniotomy; neuropathic pain.
Anticonvulsants agents include six classes of drugs: selected hydantoin derivatives, barbiturates, benzodiazepines, succinimides, iminostilbene derivatives (carbamazepine), and carboxylic acid derivatives. Some hydantoin derivatives and carbamazepine inhibit the spread of seizure activity in the motor cortex.
Some barbiturates and succinimides limit seizure activity by increasing the threshold for motor cortex stimuli. Selected benzodiazepines and carboxylic acid derivatives may increase inhibition of GABA in brain neurons.
Anticonvulsants can cause adverse CNS effects, such as ataxia, confusion, somnolence, and tremor. Many anticonvulsants also cause CV disorders, such as arrhythmias and hypotension; GI effects, such as vomiting; and hematologic disorders, such as agranulocytosis, bone marrow depression, leukopenia, and thrombocytopenia.