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1. Question
In a patient who has had documented gouty arthritis and hyperuricemia and who also has hypertension, a preferred antihypertensive agent would be,
Correct
Answer & Explanation:
The answer is B
Explanation:
Losartan, an angiotensin II receptor blocker has been shown to increase urinary uric acid secretion and can, therefore, lower serum uric acid levels. Hydrochlorothiazide actually decreases urinary uric acid excretion and must be used cautiously in gout patients, if at all. Th e other antihypertensive agents mentioned have minimal or no eff ects on the serum uric acid.
Incorrect
Answer & Explanation:
The answer is B
Explanation:
Losartan, an angiotensin II receptor blocker has been shown to increase urinary uric acid secretion and can, therefore, lower serum uric acid levels. Hydrochlorothiazide actually decreases urinary uric acid excretion and must be used cautiously in gout patients, if at all. Th e other antihypertensive agents mentioned have minimal or no eff ects on the serum uric acid.
Losartan (Cozaar)
Losartan (Cozaar), an angiotensin II receptor blocker (ARB), might be a usefulb antihypertensive agent in the patient who has both hyperuricemia and hypertension because this agent can lower serum uric acid levels by inhibiting the uptake of uric acid by the urate anion exchange transporter in the proximal tubule. Th is eff ect is minimal or not seen in other ARBs.
