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Cimetidine (Tagamet)
- Can be administered orally, intramuscularly, or intravenously
- Food reduces the rate of absorption; if taken with meals, absorption will be slowed.
- Intravenous administration can cause hypotension and dysrhythmias.
- Antacids can decrease the absorption of oral cimetidine.
- Cimetidine and antacids should be administered at least 1 hour apart from each other.
- Cimetidine passes the blood-brain barrier, and central nervous system side effects can occur; it may cause mental confusion, agitation, psychosis, depression, anxiety, and disorientation.
- Dosage should be reduced in clients with renal impairment.
- If cimetidine is administered with warfarin sodium (Coumadin), phenytoin (Dilantin), theophylline, or lidocaine, the dosages of these medications should be reduced.
