NCLEX RN Practice Question # 390


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Cimetidine (Tagamet)

  1. Can be administered orally, intramuscularly, or intravenously
  2. Food reduces the rate of absorption; if taken with meals, absorption will be slowed.
  3. Intravenous administration can cause hypotension and dysrhythmias.
  4. Antacids can decrease the absorption of oral cimetidine.
  5. Cimetidine and antacids should be administered at least 1 hour apart from each other.
  6. Cimetidine passes the blood-brain barrier, and central nervous system side effects can occur; it may cause mental confusion, agitation, psychosis, depression, anxiety, and disorientation.
  7. Dosage should be reduced in clients with renal impairment.
  8. If cimetidine is administered with warfarin sodium (Coumadin), phenytoin (Dilantin), theophylline, or lidocaine, the dosages of these medications should be reduced.

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