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GASTRIC PROTECTANTS (Medications)
- Misoprostol (Cytotec)
- An antisecretory medication that enhances mucosal defenses
- Suppresses secretion of gastric acid and maintains submucosal blood flowby promoting vasodilation
- Used to prevent gastric ulcers caused by nonsteroidal anti-inflammatory drugs and aspirin.
- Administered with meals
- Causes diarrhea and abdominal pain
- Contraindicated for use in pregnancy
- Sucralfate (Carafate)
- Creates a protective barrier against acid and pepsin.
- Administered orally; should be taken on an empty stomach
- May cause constipation
- May impede absorption of warfarin sodium (Coumadin), phenytoin (Dilantin), theophylline, digoxin (Lanoxin), and some antibiotics; should be administered at least 2 hours apart from these medications.
