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1. Question
Regarding the mechanism of action for local anesthetics, the following are true, except:
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The correct answer is C. During the depolarization of the neuron, there is an influx of sodium. Local anesthetics act by increasing the threshold for the opening of sodium channels.
An inactive nerve cell has a resting membrane potential of −50 to −70 mV. The cytoplasm of a resting nerve cell has a high concentration of potassium ions and a low concentration of sodium ions. This gradient is maintained by a Na/K ion pump.During the repolarization of the peripheral nerve, potassium ions pass out of the cell to restore the resting cell to resting membrane potential. Non-ionized molecules enter through nerve cell membranes more readily than ionized molecules. The local anesthetics lipophilic aromatic ring facilitates passage through the nerve sheath and membrane.Incorrect
The correct answer is C. During the depolarization of the neuron, there is an influx of sodium. Local anesthetics act by increasing the threshold for the opening of sodium channels.
An inactive nerve cell has a resting membrane potential of −50 to −70 mV. The cytoplasm of a resting nerve cell has a high concentration of potassium ions and a low concentration of sodium ions. This gradient is maintained by a Na/K ion pump.During the repolarization of the peripheral nerve, potassium ions pass out of the cell to restore the resting cell to resting membrane potential. Non-ionized molecules enter through nerve cell membranes more readily than ionized molecules. The local anesthetics lipophilic aromatic ring facilitates passage through the nerve sheath and membrane.
